Lectures are one of the major teaching methods at University, but many academics are disillusioned about the value of lectures because of poor attendance and ineffective note-taking by students. Tablet technology in lectures has the potential to promote student engagement and improve note-taking. In this study, a case control design was used to investigate the effect of Tablet lectures on note-taking and attitudes of first-year bioscience students. The results of the study could possibly add to our knowledge of the use of Tablet technology in lectures to large numbers of students.